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Original Article
Prevention of Chronic Lung Disease with Early Dexamethasone Treatment in less than 32 Weeks Premature : Randomized Controlled Study
So Yun Shim, Su Jin Cho, Eun Ae Park
Clin Exp Pediatr. 2004;47(5):521-526.   Published online May 15, 2004
Purpose : The optimal timing and the consequences of dexamethasone therapy in chronic lung disease remain unknown. The purpose of this study was to determine whether early dexamethasone therapy would reduce the incidence of chronic lung disease and to determine the adverse effects and complications of prematurity associated with such therapy. Methods : Twenty neonates with hyaline membrane disease(dexamethasone n=10, placebo...
Natural History of Chronic Hepatitis B in Children
Yuria Kim, Seoung Yeon Baek, Ji Hyun Eom, Ki Sup Chung
Clin Exp Pediatr. 2004;47(3):282-289.   Published online March 15, 2004
Purpose : We investigated the spontaneous seroconversion rate of hepatitis B viral markers and predictive factors affecting seroconversion in children with chronic hepatitis B. Methods : The study population included 214 children diagnosed as chronic hepatitis B, with positive HBsAg, HBeAg and HBVDNA over six months, and all patients had a family history of chronic Hepatitis B. They were followed between...
The Effect of Post-natal Weight Changes on the Development of Bronchopulmonary Dysplasia in Infants with Respiratory Distress Syndrome
Hye One Jhon, Young Min Kim, Hee Joo Hong, Chong Woo Bae
Clin Exp Pediatr. 2004;47(3):269-274.   Published online March 15, 2004
Purpose : The subjects were compared and measured for differences in the aspects of weight changes between the groups that developed bronchopulmonary dysplasia(BPD) after treatment and those that did not, to analyze the relations between the patterns of early weight change after birth and the development of BPD. Methods : Retrospective analysis of medical records were performed for birth weight and...
The Effect of Histologic Chorioamnionitis on the Development of Respiratory Distress Syndrome and Chronic Lung Disease in Preterm Infants
Heui seung Jo, Beyong Il Kim, Chang Won Choi, Jun Dong Park, Chong Jai Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2004;47(2):150-156.   Published online February 15, 2004

Purpose: Histologic chorioamnionitis may play a role in the development of respiratory distress syndrome(RDS) and chronic lung disease(CLD) independently or through its association with preterm birth. We investigated the relationship between histologic chorioamnionitis and clinical complications including, RDS and CLD, of preterm infants. Methods: Clinical data were collected retrospectively from 478 preterm infants(gestational period≤34 weeks) who were admitted to the neonatal...
Clinical Characteristic of Chronic Autoimmune Thyroiditis in Children
Hye Rim Chung, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2004;47(1):76-80.   Published online January 15, 2004
Purpose : Although chronic autoimmune thyroiditis(AIT) is known to progress into overt hypothyroidism in adults, the outcomes of this disorder in pediatric patients are different from those in adults, so it is hard to predict its course. We reviewed clinical characteristics of chronic AIT in children. Methods : The medical records of 94 children, who were diagnosed as AIT, were analyzed,...
The Efficacy of Proximal Esophageal 24-hour pH Monitoring in Infants with Chronic Cough
Yun Hee Kim, Ja Kyoung Kim, Jung Hee Kim, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 2003;46(12):1242-1247.   Published online December 15, 2003
Purpose : Gastroesophageal reflux disease(GERD) is known as one of the most common causes of chronic cough, especially in children. The purpose of this study is to evaluate the efficacy of parameters from proximal esophageal 24-hr pH monitoring through its comparison with those of distal esophageal 24-hr pH monitoring that we generally use for diagnosis of GERD. Methods : We performed...
The Etiologic Diseases and Diagnostic Usefulness of Color Doppler Ultrasonography in Children with Chronic Coughs
Sun Young Park, Joon Sung Lee
Clin Exp Pediatr. 2002;45(4):489-497.   Published online April 15, 2002
Purpose : The objectives of this study were to investigate the causes of chronic cough and to establish the appropriate diagnostic approach to chronic cough in children. Methods : One hundred and thirty two cases of chronic cough were prospectively evaluated. They visitors to pediatric chronic cough clinics at Kang-nam saint Mary's Hospital of Catholic University from August 2000 to...
Usefulness of Chest High-Resolution CT in Patients with Chronic Cough Below 2 Years of Age
Myung Hyun Kim, Jung Hee Kim, Dae Hyun Lim, Byong Kwan Son, Kyung-Hee Lee
Clin Exp Pediatr. 2002;45(3):339-345.   Published online March 15, 2002
Purpose : The purpose of this study was to evaluate the clinical usefulness of chest high-resolution computed tomography(HRCT) in patients with chronic coughs or persistent wheezing with normal chest X-ray finding. Methods : We reviewed the charts, chest X-rays, and HRCT findings of patients with chronic coughs or persistent wheezing of less than 2 years of age. The records were sourced...
Classification and Risk Factors for Chronic Lung Disease(CLD) of Prematurity : Classical CLD Versus Atypical CLD
Chang Won Choi, Beyong Il Kim, Heui Seung Jo, Jun Dong Park, Chong Jae Kim, Bo Hyun Yoon, Jung-Hwan Choi
Clin Exp Pediatr. 2001;44(11):1222-1232.   Published online November 15, 2001
Purpose : We tried to classify the different type of CLD and assess the risk factors for classical CLD and atypical CLD. Methods : Retrospective cohort analysis was done in 120 preterm infants with birth weights less than 1,500 g who were admitted to NICU in Seoul National University Children's Hospital between Jan. 1993 and Dec. 1998 and survived more...
Growth and Neurodevelopmental Outcome at 15 Months of Corrected Age in Very Low Birth Weight Infants with Chronic Lung Disease
Seon Young Kim, Chang Yee Cho, Young Youn Choi
Clin Exp Pediatr. 2001;44(10):1112-1118.   Published online October 15, 2001
Purpose : This study was performed to compare the growth and neurodevelopmental outcome at 15 months of corrected age in very-low-birth weight infants between chronic lung disease(CLD) group and the control group. Methods : Very-low-birth-weight infants who were admitted and survived in the NICU(neonatal intensive care units) of Chonnam Univeristy Hospital from Jan. 1997 to Jan. 2000 were divided into...
Case Report
A Case of Chronic Pneumonitis of Infancy in Pediatric Interstitial Lung Disease
Hyun Oh Jang, Se Chang Ham, Young Kyoun Kim, Se Wook Oh, Yong Won Park
Clin Exp Pediatr. 2001;44(9):1085-1090.   Published online September 15, 2001
The interstitial lung diseases(ILD) comprises a large, heterogeneous group of disorders characterized by derangement of alveolar walls and alveolar capillary unit causing restrictive pulmonary dysfunction and disordered gas exchange. It is rare, especially in children, and the opinions on investigation and treatments are controversial. The classification of adult ILD is applied to that of children. But considering occurrence during the developing state of lung...
A Case of Chronic Active Epstein-Barr Virus Infection with Coronary Aneurysm
Hee Jeong, Bong Seong Kim, Ok Ja Choi, Han Wook Yoo, So Duk Lim, Soo-Jong Hong
Clin Exp Pediatr. 2001;44(6):687-693.   Published online June 15, 2001
Chronic active Epstein-Barr virus infection(CAEBV) is a nonfamilial syndrome that shows a specific immunodeficiency for the Epstein-Barr virus(EBV). CAEBV is characterized by fever, lymphadenopathy, splenomegaly, hepatitis, interstitial pneumonitis, interstitial nephritis, and uveitis. Cardiovascular complications are rare in EBV infection. Patients with CAEBV show characteristically high titers of anti-viral capsid antigen(VCA) IgG antibody and anti-early antigen(EA) antibody, as well as relatively...
Original Article
Factors Related to the Development of Microalbuminuria in Children and Adolescents with Type 1 Diabetes Mellitus
Min Ho Jung, Pei Tai Wan, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2001;44(5):577-586.   Published online May 15, 2001
Purpose : We observed the prevalence rate of microalbuminuria(MA) and its relationship with the various clinical factors in children and adolescents with type 1 diabetes mellitus(DM). Methods : Seventy two children and adolescents(26 males and 46 females, 17.1±3.0 years) were included. MA was defined as 24 hour urine microalbumin >30mg/day(20μg/min). Subjects were classified into three groups(normoalbuminuria, transient MA, or persistent MA)....
Prevalence and Epidemiologic Charicteristics of Chronic Recurrent Headache in Primary School Children
Young-Il Rho, Young-Bong Park, Eun Seok Yang, Sang Kee Park, Eun Youngn Kim, Jong Park, Kyung-Rye Moon
Clin Exp Pediatr. 2001;44(2):119-126.   Published online February 15, 2001
Purpose : The purpose of the study was to determine the prevalence of chronic recurrent headache and the factors associated with it among primary school children. Methods : The survey was performed by a special questionnaire on one thousand and eleven children in grades 4 to 6 at primary schools from 1 to 30 June 1999 in Gwangju city. Results : Prevalence...
A Study on the Effect of the Combined Use of Gentle Ventilation and High-Frequency Ventilation on the Incidence of Chronic Lung Disease
Ji Yeon Baek, Jae Han Kim, Kyung Ae Park, Suk Ho Kang, Man Hoe Hur, Sang Geel Lee
Clin Exp Pediatr. 2000;43(12):1544-1551.   Published online December 15, 2000
Purpose : This study was conducted to determine the correlation between the incidence of chronic lung disease and the combined use of gentle ventilation and high-frequency ventilation. Methods : The subject group consisted of 63 very low birthweight infants of less than 1500gm who were born and survived through ventilator treatment in the Fatima neonatal intensive care unit for four...
Case Report
A Case of Chronic Granulomatous Disease in which Enterococci were Observed in Culture
Kyunglae Cho, Jeonghee Kim, Eunjeong Kim, Churwoo Yoo, Chunsoo Kim, Unseok Nho, Chulkyu Kim
Clin Exp Pediatr. 2000;43(6):846-850.   Published online June 15, 2000
Chronic granulomatous disease(CGD) is a genetically inherited disorder caused by the failure of phagocytic cells to produce superoxide. It is characterized by frequent and uncontrollable infection which often lead to death in early childhood. The first clinical signs may be confined to skin and manifest themselves as abscesses, pyoderma, eczema or draining sinuses. The disease was first reported in 1957...
A Month-Old Infant with Chronic Granulomatous Disease Presented as Pulmonary Aspergillosis
SY Bae, JH Jung, KH Kim, YM Hong, HS Koo, JY Seoh, KS Hong, ES Kang, YS Won, JH Yoo
Clin Exp Pediatr. 2000;43(3):444-449.   Published online March 15, 2000
Chronic granulomatous disease(CGD) is an uncommon inherited disorder in which phagocytic cells fails to produce antimicrobial superoxide(O2-) due to NADPH oxidase deficiency. This disease can be easily screened by PMA(phobol myristate acetate)-activated nitroblue tetrazolium(NBT) test. Also the disease has features of chronic pyogenic infection, granuloma formation, anemia, hypergammaglobulinemia, and leukocytosis. Treatment uses antibiotics sensitive to specific organism, surgical drainage...
Original Article
Study of Autoantibodies Against Platelet GP IIb/IIIa and GP Ib/IX in Childhood Chronic Idiopathic Thrombocytopenic Purpura
Chanwook Woo, Junghwa Lee, Kwangchul Lee, Soonkyum Kim
Clin Exp Pediatr. 2000;43(3):395-401.   Published online March 15, 2000
Purpose : Chronic idiopathic thrombocytopenic purpura(CITP) is an autoimmune disease caused by autoantibodies reacting to certain antigens, and platelet glycoprotein(GP) IIb/IIIa and GP Ib/IX complexes are thought to be some of those antigens. However, the clinical significance of anti-GP autoantibodies in CITP patients is unknown. In this study, we investigated the clinical correlation between the presence of circulating autoantibodies against...
Hepatitis B Virus Precore and Core Promotor Mutations in Children with Chronic Hepatitis B Infection
Woo Yeong Chung, Jin Kuk Kim, Yeong Hoon Kim, Yeong Hong Park, Chul Ho Kim
Clin Exp Pediatr. 1999;42(10):1392-1402.   Published online October 15, 1999
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 31 children with chronic HBV infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Twenty-nine adr type were analyzed. The mutations...
Short Term Effect of Recombinant Human Growth Hormone Therapy in Children with Chronic Renal Failure
Si-Whan Ko, Dong-Kyu Ji
Clin Exp Pediatr. 1998;41(9):1256-1261.   Published online September 15, 1998
Purpose : Growth retardation is one of the major side effects of chronic renal failure. In this study, the short-term growth promoting effect, effect on the chemical parameters, and probable side effects of growth hormone treatment to child patients with chronic renal failure were examined. Methods : The research sample was 5 child patients diagnosed with chronic renal failure and receiving...
Gastroesophageal Reflux Disease in Children with Chronic Cough
Pan Joo Lim, Jae Ock Park, Dong Hwan Lee, Sang Mann Shin, Dong Won Kim
Clin Exp Pediatr. 1998;41(9):1234-1242.   Published online September 15, 1998
Purpose : We investigated the incidence of gastroesophageal reflux disease(GERD) by 24-hour esophageal pH monitoring in patients who had chronic cough for more than 3 weeks. Methods : From January 1995 to August 1996, 33 patients with chronic cough which had lasted for more than 3 weeks were enrolled in the 24-hour esophageal pH monitoring. The result was interpreted with the...
Case Report
A Case of Chronic Granulomatous Disease Which is Improved by Interferon-γ Therapy
Jae Choon Kim, Soon Seong Park, Myung Ja Yun, Dong Hyuk Keum
Clin Exp Pediatr. 1997;40(7):1021-1025.   Published online July 15, 1997
Chronic granulomatous disease is a group of rare disorders characterized by a disease of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia, anemia and leukocytosis. We experienced a case of chronic granulomatous disease with chronic recurrent infection, hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The result of patient' s...
Original Article
The Therapeutic Effect of Interferon-alpha Treatment in Children with Chronic Hepatitis B
Il Sang Jeong, Ki Sup Chung
Clin Exp Pediatr. 1997;40(7):955-964.   Published online July 15, 1997
Purpose : The prevalance rate of chronic hepatitis B viral infection in children is high in our contry. We performed a prospective study to evaluate the effectiveness of and the factors predictive of response to interferon-alpha therapy in children with chronic hepatitis B. Methods : Thirty-two children with chronic hepatitis B werew admitted to the Department of Pediatrics, Yonsei University College of Medicine from...
Myocardial Functions Estimated by Pulsed Doppler Echocardiography in Patientswith Chronic Renal Failure
Hyun June Huh, Byung Ho Choi, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1996;39(12):1712-1728.   Published online December 15, 1996
Purpose : The objectives of this study were to estimate myocardial functions in patients with chronic renal failure by pulsed Doppler echocardiography, and investigate correlation between Doppler and disease parameters. Methods : We studied 13 patients with chronic renal failure whose creatinine clearance rate less than 25ml/min. Using pulsed Doppler echocardiography with curve following method, we measured peak velocity, mean velocity, velocity-time integral and peak...
A Study about IgG Subclasses Concentration of Chronic Cough Patient and Changes of Immunoglobulin Levels after RU 41.740 Administration
Yun Sun Choi, Yang Woo Kim, Seok Jung Yun, Hyung Ku Cho, Kee Hyuck Kim
Clin Exp Pediatr. 1996;39(10):1385-1394.   Published online October 15, 1996
Purpose : People who suffer from chronic or recurrent respiratory disease have immunoglobulin deficiency due to hypofunction of B cell. Among these immunoglobulin deficiency, it has been reported that only one or two subclass of IgG are deficient with normal quantity of IgG and IgA. Therefore it is necessary to measure IgG subclasses in chronic or recurrent respiratory infection for diagnosis. The purpose of...
Case Report
A Case of Intestinal Neuronal Dysplasia
Se Young Kim, Yon Ho Choe, Jeong Kee Seo, In One Kim, Chong Jai Kim
Clin Exp Pediatr. 1996;39(8):1151-1157.   Published online August 15, 1996
Intestinal neuronal dysplasia(IND) is a disease characterized clinically by symptoms of intestinal obstruction and pathologically by hyperplasia of the submucosal and myenteric plexuses with formation of giant ganglia. Chronic intestinal pseudo-obstruction is a clinical diagnosis, composed of myopathic form and neuropathic form, and normal intestinal histology. Intestinal neuronal dysplasia is a neuropathic form of chronic intestinal pseudo-obstruction. The clinical presentation and the course of IND...
Original Article
Genital Mycoplasmasin the Newborn Infants: Colonization, Prevalence and Clinical Significance
Yun Sil Chang, Sung Gwon Kim, Beyong Il Kim, Won Soon Park, Bo Hyun Yoon, Eui Chong Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1996;39(8):1084-1094.   Published online August 15, 1996
Purpose : The genital mycoplasmas: Ureaplasma urealyticum and Mycoplasma hominis have recently assumed an increasing importance as neonatal pathogens especially in preterm infants. The aim of the present study was to determine the prevalence of infections with these organisms in newborn infants who were admitted in Neonatal Intensive Care Unit(NICU) and who were suspected having infection in newborn nursery Methods : Sixty four inborns who...
The Effect of Recombinant Human Growth Hormone on the Growth in the Children with Chronic Renal Failure
Sei Won Yang, Young Choi
Clin Exp Pediatr. 1996;39(7):997-1004.   Published online July 15, 1996
Purpose : We observed the effect of three year-administration of recombinant human growth hormone(rhGH) on the growth in the children with chronic renal failure(CRF). Methods : Five prepubertal children(three boys and two girls) with CRF, who had been managed by conservative methods, were given rhGH(1 U/kg/week) for three years. Growth parameters, such as growth velocity, height standard deviation score(SDS), and predicted final adult height, obtained...
Case Report
A Case of Chronic Recurrent Multifocal Osteomyelitis
Weon Young Lee, Eell Ryoo, Mi Jin Jeong, Kye Hwan Seol, Kil Hyen Kim, Hak Su Lee
Clin Exp Pediatr. 1996;39(5):732-737.   Published online May 15, 1996
Chronic recurrent multifocal osteomyelitis(CRMO) is an unusual inflammatory process involving multiple osseous sites. No causative agent can be consistently isolated from these lesions despite multiple biopsies and the affected child purses a clinical course of chronic remissions and exacerbations independent of antibiotic therapy. Biopsy of the lesions did not reveal any pathogens. Immunologic investigation revealed no abnormality common to the patient...
A Case of Chronic Granulomatous Disease Associated with Pyogenic Liver Abscess
S.K. Lee, J.H. Kim, S.Y. Kim, E.T. Oh, H.J. Kang, K.S. Kim
Clin Exp Pediatr. 1996;39(4):585-590.   Published online April 15, 1996
We have experienced a case of chronic granulomatous disease associated with pyogenic liver abscess in 10 years old male Chronic granulomatous disease(CGD) is a hereditary disorder of neutrophil with defective killing and digesting of ingested catalase-positive bacteria or fungi in spite of normal phagocytosis. It was diagnosed by clinical finding and laboratory examination including NBT test. Pyogenic liver abscess in old...
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